A group of independent observers affiliated with the US National Institutes of Health questioned the information provided by AstraZeneca about the effectiveness of its vaccine, and accused the company of providing outdated information, and called on it to provide recent and more accurate data about the AstraZeneca vaccine, according to what was published by AstraZeneca. Associated Press American Tuesday 23 March 2021.
While the AstraZeneca vaccine laboratory defended its vaccine, which a large number of Europeans refuse to receive, stressing that it is effective in the elderly and does not increase the risk Get blood clotsThe European Medicines Agency and the World Health Organization, in turn, defended the British “effectiveness of the vaccine.”
Questioning the efficacy of the AstraZeneca vaccine
Restoring confidence in the AstraZeneca vaccine was what AstraZeneca aspired to achieve on Monday, March 22, when it announced that an American study of 32,000 volunteers showed that its vaccine was 79% effective in preventing symptoms of Coronavirus disease, and that all volunteers who received The vaccine did not develop a serious degree of disease and were not hospitalized.
Shortly after midnight, however, the US National Institutes of Health issued a statement saying that the independent observers overseeing the study “expressed concern that AstraZeneca may have provided outdated information from that trial that may have resulted in an incomplete view of vaccine efficacy data.”
The National Institutes of Health urged the company to make sure to “publish the latest and most accurate data on the effectiveness of its vaccine as soon as possible.”
What baffled experts abroad
However, this dispute surprised the experts abroad and confused them. But they indicated that the Food and Drug Administration will eventually review all the data before deciding whether the AstraZeneca vaccine can be introduced in the United States.
“It seems that no matter how wrong this step is, the data will eventually repair itself,” said Dr. Jesse Goodman, a professor at Georgetown University and former head of the vaccines division at the US Food and Drug Administration.
Dr. Anthony Fauci of the National Institutes of Health said on ABC’s “Good Morning America” that this incident “is in fact what we call an unintended mistake” and that he expects the inconsistency to be corrected.
It is noteworthy that every vaccine trial is supervised by the “Data and Safety Monitoring Board”, which is known as the DSMB. These councils include scientists and statisticians who have no ties to the government or vaccine manufacturers.
AstraZeneca is defending its vaccine
In the study of the AstraZeneca vaccine, just like the studies of other vaccines used, some participants receive the real vaccine and the rest receive placebo vaccines, and neither they nor their doctors know which is the real or which is the placebo. Only the Data and Safety Control Board can determine who received this or that and take a quick look at the volunteers ’performance before completing the study.
The Data and Safety Monitoring Board monitors safety concerns, and also determines when the study reaches pre-defined final stages that indicate that it is time to assess the effectiveness of the vaccine. It was a data and safety oversight board appointed by the National Institutes of Health that raised concerns about the data provided by AstraZeneca, in a letter first published by The Washington Post and The New York Times.
On Tuesday, March 23, the company, the producer of the AstraZeneca vaccine, said that the data it announced for the first time included cases of Covid infection as of February 17, as it defined the rules of the study, and that it is continuing to study the cases that appeared after that. She said the initial analysis of more recent data was consistent with what it had already announced.
While the virus continues to spread
Despite doubts about the feasibility and effectiveness of some vaccines, such as the AstraZeneca vaccine, rich countries have accelerated vaccination campaigns, but concerns are growing about supplying vaccines to the rest of the world.
United Nations Secretary-General António Guterres wrote in a tweet, Wednesday, March 24: “I am deeply concerned that many low-income countries have not yet received a single dose of the Coronavirus vaccine.”
“Vaccines have to be of global benefit. The world must come together to make this a reality,” he added.
The epidemic has taken a turn for the worse in many countries, with infections worldwide approaching 124 million. The daily death toll in Brazil for the first time exceeded three thousand, while its health sector is facing great difficulties with the increasing number of injuries.
Officials said, Tuesday, that medical oxygen supplies to coronavirus patients have fallen to “alarming” levels in six of Brazil’s 27 states.
The warning sparked fears of a repeat of the horrific scenes in the northern city of Manaus in January, when a lack of oxygen left dozens of patients choking.
Adele Benzacaine, a doctor working in Manaus, told AFP: “It is not possible to describe seeing families rushing to find oxygen bottles, and disagreements in front of the shop selling these bottles.” “It was like war, bombing chaos when people run in despair without knowing what to do,” she added.