By Dennis Thompson Health Day Reporter
THURSDAY, June 30, 2022 (HealthDay News)
According to scientists, saving samples of your own poop in your youth and then transplanting them when you’re old could be the key to healthy aging.
According to an opinion piece published June 30 in the journal, stool samples frozen and stored when a person is vital and healthy could potentially rejuvenate gut bacteria that have been damaged due to aging, illness or the use of antibiotics. Trends in Molecular Medicine.
Fecal transplants are already used to treat It’s hardan opportunistic insect that causes severe diarrhea in people whose gut bacteria have been wiped out by the use of antibiotics, said senior opinion writer Yang-Yu Liu, associate professor at Harvard Medical School.
By stocking up on healthy poo when you’re younger and then giving it to yourself — a process they call autologous fecal microbiota transplantation (FMT) — you might be able to stave off some of these diseases associated with poo. aging, the scientists said.
“We expect autologous FMT [stool samples collected from the host at a younger and healthier age] may be a more potent therapeutic approach to promote healthy host aging than heterologous FMT [stool samples collected from an unrelated young and healthy donor]“, added Liu.
Many stool banks have already been opened around the world, mainly to store healthy fecal samples so that they can be made available to patients with It’s hard, the researchers noted. About half a million people in the United States suffer from It’s hard each year, and about 29,000 die from the bug.
However, these establishments collect samples taken from donors and pass them on to others in need; they generally do not store individual samples for that donor’s future use.
New paper envisions a future where everyone stores their own fecal samples in anticipation of “resanitizing” their gut bacteria when they’re older.
This would be particularly beneficial because your young bacteria would not have been repeatedly exposed to antibiotics and therefore would not have had the chance to be infested with antibiotic resistant bacteriawrote the researchers.
But there are plenty of hurdles that will need to be cleared before these stool banks become a reality, the researchers added.
First, there are major security concerns – could certain bacteria in your young GI tract actually pose a threat to an older version of yourself?
Doctors will need to “identify opportunistic pathogens that are benign to young adults with strong immune systems but harmful to older adults with weakened immune systems,” Liu said.
There’s also the question of whether a fecal transplant would actually rejuvenate an aging gut microbiome, said Dr. Sahil Khanna, a gastroenterologist at the Mayo Clinic in Rochester, Minnesota.
“When you transplant gut bacteria from a younger version of yourself to an older version of yourself, do the bacteria make you younger or do the bacteria themselves age to adapt to your existing microbiome? ?” said Khanna, who was not involved in the opinion piece. “We don’t know if it’s been proven to reverse the aging of bacteria or not.”
The idea also raises many logistical problems.
Storing stool samples for decades would require expensive freezers down to -214 degrees Fahrenheit, Liu predicts — something unavailable to the average Joe.
“It’s a fun thing to think about, every person having a bank of poo in their basement freezer, but that wouldn’t be the right thing to do,” Khanna said. “The saddle bank is not a DIY proposition.”
Stool banks would also need a lot of freezer space and would require a lot of energy to run those freezers, Liu added. It will be an expensive proposition.
“We don’t expect everyone in our society to be willing to pay the price,” Liu said. “Developing a reasonable business model and marketing strategy would certainly require the joint force of entrepreneurs and scientists.”
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Also, there is no telling how much poo you will need to store for each person. It’s hard can be treated with a single fecal transplant, Khanna said, but more complex issues, like inflammatory bowel diseasewould probably require multiple transplants.
Future research will be needed to understand all of these issues, and also to help identify specific people who might be at high risk for a disease that could be treated with a fecal transplant, Khanna said.
“It’s very futuristic,” Khanna said of the newspaper. “We’re probably not there yet, but this is where we need to be.”
OpenBiome has more information on stool bank.
SOURCES: Yang-Yu Liu, PhD, associate professor, Harvard Medical School, Boston; Sahil Khanna, MBBS, gastroenterologist, Mayo Clinic, Rochester, Minnesota; Trends in Molecular MedicineJune 30, 2022
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